Safety Information
According to Tisserand & Young, Anise Seed Myrtle essential oil can be potentially carcinogenic, based on estragole & safrole content, may inhibit blood clotting & reproductive hormone modulation.
Anise Seed Myrte essential oil is contraindicated during pregnancy, breastfeeding, for those with endometriosis, estrogen dependent cancers & children under 5 yrs old
Indicated cautions: Diabetes & anticoagulant medication, peptic ulcer, hemophilia, major surgery & other bleeding disorders.
(E)-Anethole inhibits platelet aggregation. Essential oils high in (E)-anethole should therefore be avoided, especially in high or oral doses, before major surgery, and in anyone taking blood-thinning medication, or with blood coagulation issues. Essential oils with a high (E)-anethole content should be avoided during pregnancy. (E)-Anethole is weakly estrogenic in yeast cells. It is not estrogenic in breast cancer cells, but a metabolite of (E)-anethole is estrogenic. Given orally to female rats at 80 mg/kg/day for three days, (E)-anethole significantly increased uterine weight, suggesting estrogenic activity. In carcinogenesis studies, (E)-anethole did not cause breast cancer in either rats or mice.
Avoid old or oxidized oils.
Maximum daily oral dose: 53mg
Maximum dermal level per Tisserand & Young: 1.75% (based on 6.6% estragole & 0.1% safrole content) and dermal limits of 0.12% for estragole and 0.05% for safrole
References
Tisserand & Young Essential Oil Safety, 2nd Edition Churchill Livingstone Elsevier. Edinburg 2014
Mojay, Gabriel. Aromatherapy for Healing the Spirit, Healing Arts Press, Rochester, VT 1997
Battaglia, S. The Complete Guide to Aromatherapy, 2nd Edition. Queensland, Aust. 2003
Zeck, Robbi. The Blossoming Heart: Aromatherapy for Healing and Transformation. Aroma Tours, 2004.